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Edward F McKone Selected Research

Therapeutics

10/2021Factors for severe outcomes following SARS-CoV-2 infection in people with cystic fibrosis in Europe.
1/2021Triple Therapy for Cystic Fibrosis Phe508del-Gating and -Residual Function Genotypes.
10/2020Tocilizumab therapy in individuals with COVID-19 infection and hyperinflammatory state.
1/2020CFTR Modulator Therapy Enhances Peripheral Blood Monocyte Contributions to Immune Responses in People With Cystic Fibrosis.
1/2020The future of cystic fibrosis care: a global perspective.
11/2017Tezacaftor-Ivacaftor in Patients with Cystic Fibrosis Homozygous for Phe508del.
1/2017Assessment of safety and efficacy of long-term treatment with combination lumacaftor and ivacaftor therapy in patients with cystic fibrosis homozygous for the F508del-CFTR mutation (PROGRESS): a phase 3, extension study.
10/2015Sustained Benefit from ivacaftor demonstrated by combining clinical trial and cystic fibrosis patient registry data.
11/2014Long-term safety and efficacy of ivacaftor in patients with cystic fibrosis who have the Gly551Asp-CFTR mutation: a phase 3, open-label extension study (PERSIST).
11/2002Adrenal insufficiency and testicular failure secondary to megestrol acetate therapy in a patient with cystic fibrosis.

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Edward F McKone Research Topics

Disease

44Cystic Fibrosis (Mucoviscidosis)
12/2023 - 06/2002
6Lung Diseases (Lung Disease)
10/2021 - 08/2006
5Inflammation (Inflammations)
11/2022 - 01/2017
5Infections
12/2021 - 01/2017
2Pseudomonas Infections
10/2021 - 08/2006
1Exanthema (Rash)
01/2023
1Virus Diseases (Viral Diseases)
11/2022
1Psychotic Disorders (Schizoaffective Disorder)
01/2022
1Obsessive-Compulsive Disorder (Disorder, Obsessive-Compulsive)
01/2022
1Bronchiectasis
12/2021
1COVID-19
10/2020
1Persistent Infection
01/2020
1Malnutrition (Nutritional Deficiencies)
01/2020
1Lung Injury
08/2006
1Acquired Immunodeficiency Syndrome (AIDS)
11/2002
1Adrenal Insufficiency (Adrenal Gland Hypofunction)
11/2002
1Weight Loss (Weight Reduction)
11/2002
1Neoplasms (Cancer)
11/2002

Drug/Important Bio-Agent (IBA)

19ivacaftorIBA
01/2022 - 11/2011
16Cystic Fibrosis Transmembrane Conductance Regulator (Protein, CFTR)IBA
01/2022 - 05/2003
11ivacaftor drug combination tezacaftorIBA
12/2023 - 11/2017
10ChloridesIBA
12/2023 - 09/2015
10elexacaftorIBA
12/2023 - 10/2018
5tezacaftorIBA
01/2023 - 11/2017
4Anti-Bacterial Agents (Antibiotics)IBA
11/2022 - 01/2020
2Biomarkers (Surrogate Marker)IBA
11/2022 - 10/2021
2CytokinesIBA
01/2021 - 04/2020
2AnionsIBA
04/2019 - 01/2018
2lumacaftorIBA
01/2017 - 01/2015
1C-Reactive ProteinIBA
11/2022
1Oxygen (Dioxygen)IBA
10/2021
1Azithromycin (Zithromax)FDA LinkGeneric
10/2021
1dornase alfa (Pulmozyme)FDA Link
01/2021
1Interleukin-17 (Interleukin 17)IBA
01/2021
1tocilizumab (atlizumab)FDA Link
10/2020
1InterferonsIBA
04/2020
1Expectorants (Mucolytics)IBA
01/2020
1EnzymesIBA
01/2020
1ChemokinesIBA
01/2020
1VX-659IBA
10/2018
1Lysine (L-Lysine)FDA Link
11/2017
1AztreonamFDA LinkGeneric
11/2017
1Macrophage Migration-Inhibitory FactorsIBA
11/2017
1Phenobarbital (Luminal)FDA Link
08/2009
1AndrogensIBA
12/2008
1Glutamate-Cysteine LigaseIBA
08/2006
1Glutathione (Reduced Glutathione)IBA
08/2006
1Oxidants (Oxidizing Agents)IBA
08/2006
1Megestrol Acetate (Borea)FDA LinkGeneric
11/2002
1Lactic Acid (Lactate)FDA LinkGeneric
06/2002

Therapy/Procedure

10Therapeutics
10/2021 - 11/2002
2Lung Transplantation
10/2021 - 01/2019
1Aftercare (After-Treatment)
12/2021
1High-Protein Diet
01/2020